HEMATOLOGY CLINICAL PRINCIPLES AND APPLICATIONS RODAK FREE PDF

It shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. This text also makes it easy to understand complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics. Clinical lab experts Elaine Keohane, Larry Smith, and Jeanine Walenga also cover key topics such as working in a hematology lab, the parts and functions of the cell, and laboratory testing of blood cells and body fluid cells. Instructions for lab procedures include sources of possible errors along with comments.

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Section C meets the Florida requirements in hematology and molecular pathology. For ASCP, it provides 9 hours in hematology and 3 in molecular pathology. Automation and digital data management have revolutionized the way blood specimens are transported and stored, how assays are ordered, and results validated, reported and interpreted. Molecular diagnosis has augmented and in many instances replaced older laboratory assays.

Hematologic disorders have been reclassified on the basis of phenotypic, cytogenetic, and molecular genetic analyses. Diagnoses that once depended on analysis of cell morphology and cytochemical stains now rely on flow cytometry, cytogenetic testing, fluorescent in situ hybridization FISH , end point and real time polymerase chain reaction assays, gene sequencing, and microarrays.

Chemotherapeutic monitoring of leukemias and lymphomas has shifted to the management of biologic response modifiers and detection of minimal residual disease at the molecular level. Hemostasis has grown to encompass expanded thrombophilia testing, methods that more reliably monitor newly available antiplatelet and anticoagulant drugs, molecular analysis, and a shift from clot-based to functional and chromogenic assays.

The text presents basic to advanced concepts to provide a solid foundation of normal and pathologic states upon which readers may build their skills in interpreting and correlating laboratory findings in anemias, leukocyte disorders, and hemorrhagic and thrombotic conditions. Key features are provided for accurate identification of normal and pathologic cells in blood, bone marrow, and body fluids.

The focus, level and detail of hematology and hemostasis along with the related clinical applications, interpretation, and testing algorithms make this text a valuable resource for all healthcare professionals managing these disorders.

This book is divided into three sections of 12 hours each. Section A Chapters : Chapters include laboratory safety, blood specimen collection, microscopy and quality assurance in the hematology laboratory. Chapters 6 and 7 use photomicrographs and figures to describe general cellular structure and function as well as the morphologic and molecular details of hematopoiesis.

Chapters 8, 12 and 13 discuss erythropoiesis, leukopoiesis and megakaryopoiesis using photomicrographs demonstrating ultrastructure and microscopic morphology. Chapters 9 and 10 examine mature red blood cell metabolism, hemoglobin structure and function, red blood cell senescence and destruction. Iron kinetics and laboratory assessment in Chapter 11 has been substantially updated with new figures and updated coverage of systemic and cellular regulation of iron.

Chapter 13 includes detailed descriptions of platelet adhesion, aggregation and activation. Chapter 14 describes manual procedures such as microscopy based cell counts, hemoglobin and hematocrit determinations, and point of care technology. Chapter 15 includes descriptions and figures of the latest automated hematology analyzers. Chapter 17 follows with bone marrow aspirate and biopsy collection, preparation, examination and reporting.

Chapters describe disorders of iron, DNA metabolism and bone marrow failure. Chapters discuss hemolytic anemias due to intrinsic or extrinsic defects, with chapter 23 updated including new figures that detail extravascular and intravascular hemolysis and hemoglobin catabolism. Chapters 27 and 28 provide updates in pathophysiology, diagnosis, and treatment of hemoglobinopathies and the thalassemias. Chapter 29 is significantly updated with photomicrographs and summary boxes of nonmalignant systemic bacterial, viral or benign lymphoproliferative disorders manifested by the abnormal distribution or morphology of leukocytes.

Chapter 32 describes flow cytometry and its diagnostic applications. Chapters provide the latest classifications and pathophysiology models for myeloproliferative neoplasms, myelodysplastic syndromes, acute lymphoblastic and myeloblastic leukemias, chronic lymphocytic leukemias and solid tumor lymphoid neoplasms. Chapter 37 provides the plasma-based and cell-based coagulation models and the intractions between primary and secondary hemostasis and fibrinolysis with updated illustrations.

Chapter 38 details hemorrhagic disorders, including the management of the acute coagulopathy of trauma and shock. Chapter 39 updates the currently recognized risk factors of thrombosis and describes laboratory tests which identify venous and arterial thrombotic diseases, particularly for lupus anticoagulant and heparin-induced thrombocytopenia HIT testing.

Chapters 40 and 41 detail the qualitative and quantitative platelet disorders, and Chapter 42 details laboratory assays of platelets and the coagulation mechanisms. Chapter 43 covers mechanisms and monitoring methods of traditional warfarin and heparin-derived antithrombotic drugs, as well as all thrombin and factor Xa inhibitor drugs. Chapter 44 reviews the latest coagulation analyzers and point of care instrumentation.

Chapter 45 provides valuable information on hematology and hemostasis laboratory findings in pediatric and geriatric populations correlated with information from previous chapters. This text should also prove to be a valuable shelf reference for hematologists, pathologists, and hematology and hemostasis laboratory managers.

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